SS-31

SS-31, also known as Elamipretide, Bendavia, or MTP-131, is a synthetic peptide that targets and improves mitochondrial function. Mitochondria generate ATP (the body’s primary energy molecule), regulate cellular homeostasis, and impact nearly all physiological systems.

SS-31 is a mitochondrial-targeted antioxidant with extensive therapeutic potential: mitigating oxidative stress, suppressing inflammation, maintaining mitochondrial health, and preventing cellular apoptosis.

It has several advantages over natural antioxidants and plays a key role in treating mitochondrial dysfunction-related disorders.

Benefits

• Increased energy (most potent energy-boosting peptide available)
• Neutralizes free radicals and reverses oxidative stress damage
• Anti-aging
• Anti-inflammatory (including neuroinflammation)
• Supports memory and cognition
• Antifibrotic
• Beneficial for kidney disease (activates AMPK pathway)
• Fights insulin resistance
• May prevent or mitigate symptoms of:
  • Cardiovascular disease
  • Neurodegenerative conditions
  • Asthma and COPD
  • Age-related macular degeneration
  • Cancer
  • Barth syndrome
  • Primary mitochondrial myopathy
  • Duchenne muscular dystrophy
  • Friedreich’s ataxia

Possible Side Effects

• Injection site irritation (redness, swelling, and/or itching)
• Gas
• Gastrointestinal upset
• Headache
• Dizziness
• Signs of an allergic reaction include:
  • Fast, erratic heartbeat
  • Profuse sweating
  • Shortness of breath
  • Confusion
  • Severe weakness
  • Loss of coordination
  • Stiff muscles and high fever
  • Eye symptoms including blurred vision, tunnel vision, eye pain, swelling of the eyes, or seeing halos around lights

Contraindications

• Do not use if pregnant or breastfeeding
• Do not use if hypersensitive to mitochondrial-targeted compounds

Stacking Suggestions

• MOTS-C – run SS-31 before a MOTS-C cycle for maximum mitochondrial optimization. SS-31 primes the mitochondria, while MOTS-C boosts cellular adaptation and metabolic health. Follow standard protocol for 10–14 days prior to the start of the MOTS-C protocol.
• NAD+ – supports ATP production and cellular repair when paired with SS-31
• Glutathione – enhances antioxidant defense and detoxification during oxidative stress repair
• CJC-1295 / Ipamorelin – supports cellular regeneration and recovery alongside mitochondrial repair
• AOD-9604 – assists with fat metabolism during energy-focused SS-31 cycles
• BPC-157 – promotes systemic healing and combats inflammatory stress